Season 4
Episode 13 - No More Mr. Nice Guy
Brief Plot Summary
While walking the picket line, Jeff collapses as his eyes roll back into his head. House believes his extreme niceness and inability to become angry is a symptom of his condition. House believes it could be Williams syndrome. Then they believe it could be syphilis from the positive test. House decides to play a joke on the team and make them believe that he has syphilis, which is the reason he is a jerk. Kutner then realizes that it could be Chagas disease, which could explain the false positive.
While walking the picket line, Jeff collapses as his eyes roll back into his head. House believes his extreme niceness and inability to become angry is a symptom of his condition. House believes it could be Williams syndrome. Then they believe it could be syphilis from the positive test. House decides to play a joke on the team and make them believe that he has syphilis, which is the reason he is a jerk. Kutner then realizes that it could be Chagas disease, which could explain the false positive.
Diagnosed Disease: Chagas Diseases - Tropical disease caused by the protozoan Trypanosoma cruzi causing inflammation, lesions and fibrosis.
SymptomsEarly phase is unnoticed or mild (vomiting, fever, fatigue, headaches etc.), enlarged liver, swollen eyelids (Romañas sign)
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CausesInfection from protozoan through an insect bite from the triatomine bug.
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TestsDetected through blood smear/sample.
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Treatment/CureAntiparasitics are used to treat the underlying infection while other drugs can be used to treat the symptoms.
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Source Links: Wiki
Episode 14 - Living the Dream
Brief Plot Summary
House kidnaps one of the stars of his favorite soap opera shows to run a test on his peripheral vision and address any possible neurological symptoms. As he's leaving the hospital, he has acute foot numbness. House thinks it could be autonomic dysregulation from B6 toxicity. However he goes into cardiac arrest and they shock him back to rhythm. House wants to nuke his thyroid, but the team runs an iodine uptake test to confirm a problem first which reveals a kidney failure. House then begins to test for autoimmune antibodies during which he has delirium from a high fever caused by sepsis, indicating an infection. He also slips into a coma. Foreman suggests testing for a fungal infection. However, House realizes that it could be a rare allergic vasculitis and treats him with steroids. The patient improves, but not because of a floral allergy as House predicted, but from a quinine allergy.
House kidnaps one of the stars of his favorite soap opera shows to run a test on his peripheral vision and address any possible neurological symptoms. As he's leaving the hospital, he has acute foot numbness. House thinks it could be autonomic dysregulation from B6 toxicity. However he goes into cardiac arrest and they shock him back to rhythm. House wants to nuke his thyroid, but the team runs an iodine uptake test to confirm a problem first which reveals a kidney failure. House then begins to test for autoimmune antibodies during which he has delirium from a high fever caused by sepsis, indicating an infection. He also slips into a coma. Foreman suggests testing for a fungal infection. However, House realizes that it could be a rare allergic vasculitis and treats him with steroids. The patient improves, but not because of a floral allergy as House predicted, but from a quinine allergy.
Diagnosed Disease: Allergic Vasculitis - Severe allergic reaction to a drug, infection, or any other foreign substance
SymptomsSymptoms can be systemic but usually manifest in some way on the skin unlike the episode.
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CausesTriggered by allergens from any foreign substance or drug.
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TestsTest include testing the patient's reaction to different antigens to elicit a response to find the allergic trigger; skin biopsy can also be done
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Treatment/CureMain purpose is to reduce inflammation and immune response; steroids are the best for severe cases while NSAIDs might also be prescribed.
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Source Links: NIH
Episode 15 - House's Head
Brief Plot Summary
House regains consciousness in a strip club but doesn't remember how he got there. He realizes he is concussed and suffering from retrograde amnesia. It appears he has been in a bus crash but he believes that he saw a symptom before the crash. Chase performs hypnosis on House to help him remember what happened. The bus driver then has a sudden onset of paralysis, which they treat with antibiotics for transverse myelitis. However, when his stomach start hurting House re-enters his subconscious and sees a shuffling gate which his thinks could indicate Parkinsons. The driver then begins wheezing and House notices that he has new teeth caps. After the patients O2 stats begins to fall, he stabs a syringe into the apex of his heart to remove the bubble. However, after another session in his hypnotic state, House believes someone else is dying, he finally remembers that it's Amber.
House regains consciousness in a strip club but doesn't remember how he got there. He realizes he is concussed and suffering from retrograde amnesia. It appears he has been in a bus crash but he believes that he saw a symptom before the crash. Chase performs hypnosis on House to help him remember what happened. The bus driver then has a sudden onset of paralysis, which they treat with antibiotics for transverse myelitis. However, when his stomach start hurting House re-enters his subconscious and sees a shuffling gate which his thinks could indicate Parkinsons. The driver then begins wheezing and House notices that he has new teeth caps. After the patients O2 stats begins to fall, he stabs a syringe into the apex of his heart to remove the bubble. However, after another session in his hypnotic state, House believes someone else is dying, he finally remembers that it's Amber.
Episode 16 - Wilson's Heart
Brief Plot Summary
Amber has been stabilized but she has tachycardia and they can't find a reason. House and Wilson decide to move her to Princeton Plainsboro and on the way decide to put her in protective hypothermia in an effort to have more time to diagnose her. She has jaundice meaning her liver and heart are failing. House believes it could be Hep B but they find a blue rash on her back. With deep brain stimulation, House remembers that Amber had the flu and was taking amantadine. When the crash destroyed her kidneys, the drug was left unfiltered, leading to amantadine poisoning, which can't be treated with dialysis since amantadine binds to proteins in the blood.
Amber has been stabilized but she has tachycardia and they can't find a reason. House and Wilson decide to move her to Princeton Plainsboro and on the way decide to put her in protective hypothermia in an effort to have more time to diagnose her. She has jaundice meaning her liver and heart are failing. House believes it could be Hep B but they find a blue rash on her back. With deep brain stimulation, House remembers that Amber had the flu and was taking amantadine. When the crash destroyed her kidneys, the drug was left unfiltered, leading to amantadine poisoning, which can't be treated with dialysis since amantadine binds to proteins in the blood.
Diagnosed Disease: Amantadine Poisoning - Occurs from an overdose of amantadine which is used to treat influenza. Becomes fatal when the kidneys can't filter it, thus binding to proteins in organs causing poisoning which dialysis cannot filter.
